Bismuth alpha ethyl-n-caproate and a process of making it



Patented Apr. 23, 1940 UNITED STATES PATENT OFFlCE BISMUTH c ETHYL -NGAPROATE AND A PROCESS OF MAKING IT Laszlo Vargha, Budapest, Hungary, assignor to Gedeon Richter,

Budapest, Hungary No Drawing. Application March 29, 1939, Se-

rial No. 1938 2 Claims.

This invention relates to the production of bismuth a ethyl-mcaproate.

It is known that oil-soluble organic bismuth salts show advantageous medical properties. In the literature however only a small number of such salts has been described and it has been found that generally the organic bismuth salts are either very slightly solubles in oil or not constants enough.

Researches have proved, that the bismuth salt of the a-ethyl-oaproic acid, hitherto unknown, is highly soluble in oil and shows the desired medical eifects. The new compound has the fol- Example 485 grams of bismuth nitrate are dissolved in 264,737. r In Hungary October 26,

a mixture of 1500 cc. of water. This solution is mixed by stirring with a solution of 432 grams of a-ethyl-ncaproic acid in 1500 cc. of 2n-sodium hydroxide. The bismuth salt separated is dissolved in 1250 cc. of chloroform and after having removed the water by the use of sodium sulphate, the solvent is removed by distillation after standing the solution for a day. The bismuth-u-ethyl-n-caproatez /CH.C O 0 02 5 3.Bi

is a colourless oil, very soluble in ether and in oils. It contents 30-32% of Bi.

What I claim is: l

1. A compound having the formula:

/CH.C O 0 0211 3.131

2. A process for the production of the compound according to claim 1, in which a solution of bismuth nitrate in a mixture of glycerine and water is prepared and added to a stirred solution of u-ethyl-n-caproic acid in 2n-sodium hydroxide, the organic bismuth salt separated being dissolved in chloroform, the solution being dried after standing for a day and the solvent being removed by distillation.

LAszLo VARGHA. 

